Work

A druggable redox switch on SHP1 controls macrophage inflammation

Year: 2026

Type: article

Source: Nature Chemical Biology

DOI: 10.1038/s41589-026-02163-8

Institutions: Harvard University, Dana-Farber Cancer Institute, Stanford Medicine, Stanford University, Northeastern University, Howard Hughes Medical Institute, Dana-Farber/Harvard Cancer Center

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, Richard and Susan Smith Family Foundation, National Institutes of Health, National Institute on Aging, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, Common Fund

Awards: Defining the landscape and mechanisms of protein redox regulation during aging, G9000235851, Defining the landscape and mechanisms of protein redox regulation during aging, Targeting SHP-1 through a newfound metabolite-regulated cysteine activation site, Defining mechanisms of extracellular succinate regulation over metabolic tissue function

OpenAlex ID: W7135027975

FWCI: 5.152

Cites: 75

Cited by: 3

Related to: 10