Work

A first-principles quantitative framework for how cohesin regulators shape chromatin loop extrusion

Year: 2026

Type: article

Abstract: In this issue of Cell Genomics, Tortora and Fudenberg develop a first-principles framework in which loop extrusion is quantitatively regulated by multiple cohesin-associated factors, giving rise to "bursty extrusion." This model predicts regulator-dependent changes in motor kinetics, chromatin contact patterns, and chromosome-scale morphology across spatial scales, providing a mechanistically grounded basis for quantitative modeling of 3D genome architecture.

Source: Cell Genomics

Authors: Zibin Huang, Xinyi Liu, Junjun Ding

Institution: Sun Yat-sen University

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $8,900