CarpeDiem , a per-day clinical parameters and pneumonia adjudication dataset for critically ill patients with suspected pneumonia
Year: 2026
Type: preprint
Abstract: Many analyses of critically ill patients focus on admission features and discharge outcomes, overlooking daily events and intercurrent complications. Pneumonia is a syndromic entity that is difficult to adjudicate outcomes without clinical expertise. Here, we examine clinical features on a day-by-day basis, mirroring the practice of daily multidisciplinary rounds, with annotated pneumonia episodes and outcomes. The Successful Clinical Response in Pneumonia Therapy (SCRIPT) CarpeDiem Dataset includes 21,931 patient-hospital-days from 704 patients enrolled in the SCRIPT study between June 2018 and May 2023. These patients were all receiving mechanical ventilation and underwent bronchoalveolar lavage to diagnose and establish the etiology of their pneumonia or an alternative diagnosis. The dataset captures patient demographics, daily clinical parameters, including vital signs, laboratory results, and mechanical support data, detailed pneumonia episode results adjudicated by critical care physicians, and outcomes. All data are de-identified per HIPAA Safe Harbor guidelines. This dataset offers a unique resource for analyzing the clinical trajectories of patients with severe pneumonia.
Source: medRxiv
Authors: Catherine A. Gao, Nikolay S. Markov, Mengjia Kang, Luke V. Rasmussen, Wan-Ting Liao, Anna Pawlowski, Prasanth Nannapaneni, Vijeeth Guggilla, Helen K. Donnelly, Rebecca K. Clepp, Chiagozie Pickens, Nandita Nadig, Thomas Stoeger, Dan Schneider, Justin Starren, Theresa Walunas, G.R. Scott Budinger, Richard G. Wunderink, Alexander V. Misharin, Benjamin D. Singer, The NU SCRIPT Study Investigators
Institutions: Northwestern University, Northwestern Medicine
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G2056304158, Northwestern University Clinical and Translational Science Institute (NUCATS), G3179776513, Epigenetic modifiers of regulatory T cell function following viral pneumonia, Lung transplant injury drives chronic lung allograft dysfunction via recruitment ofmonocyte-derived alveolar macrophages, CRITICAL: Collaborative Resource for Intensive care Translational science, Informatics, Comprehensive Analytics, and Learning, Modeling the Incompleteness and Biases of Health Data, G5833551633, Machine learning approaches to predict outcomes and complications in ICU patients, Disordered Proteostasis as a Driver of Disease in the Aging Lung, Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgery, Mechanisms of regulatory T cell-mediated recovery from severe viral pneumonia, Targeting abnormal alveolar immune activation and failed epithelial repair in COVID-19, Midwest Murine-Tissue Mapping Center (MM-TMC), Successful Clinical Response In Pneumonia Therapy (SCRIPT) Systems Biology Center, The Neu-Lung Consortium: Neutrophilic Mechanisms of Inflammation, Injury, and Repair in Lung and Airways Diseases, Pathogenesis of lung injury mediated by lung-restricted antibodies, Mechanisms of Recovery from Viral Pneumonia
OpenAlex ID: W7135077654