TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
Year: 2026
Type: article
Abstract: Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome-based therapies have demonstrated diverse functional potential, the regulatory mechanisms underlying their biogenesis and secretion remain poorly understood. Here, we report that TEAD1 functions as a molecular switch, dramatically enhancing the synthesis and secretion of exosomes. Mechanistically, TEAD1 enhances exosome secretion by promoting the expression of exosome secretion-associated proteins RAB11, CD9, and SNAP23. We found that TEAD1 enhances exosome secretion from adipose-derived mesenchymal stem cells, thereby promoting skin wound healing in diabetic mice. Similarly, TEAD1 promotes the release of exosomes from bone marrow-derived mesenchymal stem cells, thereby facilitating spinal cord injury (SCI) repair. Our study elucidates a novel role for TEAD1 in driving exosome secretion in different cell types, highlighting the therapeutic potential of TEAD1 in enhancing tissue regeneration, particularly in diabetic wound healing and SCI repair.
Source: Advanced Science
Institutions: Fudan University, Pudong Medical Center, Tsinghua University, Shanghai Jiao Tong University, XinHua Hospital, Xinjiang Medical University, Tumor Hospital of Xinjiang Medical University, Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,730
OpenAlex ID: W7135095484