Work

PU.1: the conductor of Alzheimer’s symphony

Year: 2026

Type: article

Abstract: A recent study by Ayata et al. (2025) reveals that the transcription factor PU.1 acts as a molecular switch that determines whether microglia protect against or worsen Alzheimer’s disease pathology, with lower PU.1 levels promoting beneficial microglial states that reduce amyloid burden and neuroinflammation.

Source: Molecular Neurodegeneration

DOI: 10.1186/s13024-026-00937-1

Authors: Chunli Sun, Qianjin Liu

Institution: Xuzhou Medical College

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090