Work

Generation of four induced pluripotent stem cell lines from Korean patients with Huntington’s disease (IPBi001-A, IPBi002-A, IPBi003-A, IPBi004-A)

Year: 2026

Type: article

Abstract: Human induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) of four Korean patients with Huntington's disease using a non-integrating Sendai virus-based reprogramming method. The iPSC lines expressed pluripotency markers, as confirmed by immunocytochemistry (OCT4, NANOG, SSEA-4) and flow cytometry (TRA-1-60, TRA-1-81, SSEA-4), and showed trilineage differentiation potential in vitro. All lines retained normal karyotypes and short tandem repeat (STR) profiles identical to parental PBMCs, with complete clearance of Sendai virus. These patient-derived iPSCs provide a valuable resource for Huntington's disease modeling, drug discovery, and efficacy evaluation.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.103963