Year: 2026
Type: preprint
Study design: Observational Study
Abstract: ABSTRACT Plasma biomarkers of Alzheimer’s pathology have been studied in relation to cognitive decline and dementia, but no prior study has examined their associations with longevity or healthspan. In this cohort study of older women (N=2,576), we examined plasma biomarkers measured at baseline when women were cognitively unimpaired. We found that plasma biomarkers were associated with both exceptional longevity and healthspan, defined as survival to age 90 without cognitive impairment. Elevated levels of plasma p-tau217 (OR, 0.58; 95% CI, 0.50-0.68), p-tau181 (OR, 0.81; 95% CI, 0.71 – 0.93), NfL (OR, 0.70; 95% CI, 0.60 – 0.82) and GFAP (OR, 0.78; 95% CI, 0.68 – 0.90) were all associated with reduced odds of healthspan; findings survived adjustment for multiple comparisons. These findings suggest that plasma biomarkers may not only reflect ADRD pathology but also systemic aging processes that underlie lifespan and healthspan, underscoring their potential value as novel biomarkers of aging.
Source: medRxiv
Institutions: University of California San Diego, National Institutes of Health, National Institute on Aging, University of Pennsylvania, Beth Israel Deaconess Medical Center, Harvard University, University of Washington, University of Minnesota, Kaiser Permanente Washington Health Research Institute
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1211708387, Plasma proteomic signatures of physical activity and Alzheimer's disease and related dementias, G3827278403, G4499735890, G4816276850, G554960330, G571830633, G5777902738, G6238440229, Objective Physical Activity and Cardiovascular Health in Women Aged 80 and Older, G6374953548, G6894818919, G7159829730, G7348868804, G7821233859, G796413602, G8566225511, G8836210513, Immune Cells in Alzheimer’s Disease and Related Dementias in the Jackson Heart Study
OpenAlex ID: W7135152925