Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients With HIV
Year: 2026
Type: article
Study design: Observational Study
Abstract: People with HIV-1 have higher risk for rejection after kidney transplantation but the mechanism is poorly understood. As HIV latency promotes immune dysregulation and chronic inflammation, we evaluated whether the size of the HIV latent viral reservoir (LVR) at baseline and through 52-weeks is associated with rejection in kidney transplant recipients with HIV from donors with and without HIV. Using the intact proviral DNA assay, we found no differences in the LVR between those who experienced rejection (n = 14) versus those who did not (N = 55) regardless of donor HIV status. These data support the feasibility of HIV+ to HIV+ organ transplantation. Clinical Trials Registration. NCT03500315.
Authors: Andrew Sulaiman, Miruthula Tamil Selvan, Ping Yang, Xianming Zhu, Yolanda Eby, Sarah E Benner, Reinaldo E Fernandez, Sarah Hussain, Diane Brown, Niraj Desai, Sander Florman, Meenakshi M Rana, Rachel Friedman-Moraco, Marcus R Pereira, Shikha Mehta, Peter Stock, Alexander Gilbert, Michele I Morris, Valentina Stosor, Sapna A Mehta, Catherine B Small, Karthik Ranganna, Carlos A Q Santos, Saima Aslam, Maricar Malinis, Nahel Elias, Emily A Blumberg, Allan Massie, Melissa L Smith, Megan Morsheimer, Gregory M Laird, Robert Siliciano, Dorry L Segev, Christine M Durand, Andrew D Redd, Aaron A R Tobian
Institutions: Johns Hopkins University, Johns Hopkins Medicine, Icahn School of Medicine at Mount Sinai, Emory University, Columbia University Irving Medical Center, University of Alabama, University of Alabama at Birmingham, NYU Langone Health, UAB Medicine, New York University, University of California, San Francisco, Georgetown University, University of Miami, Northwestern University, Weill Cornell Medicine, Drexel University, University of Pennsylvania, Rush University Medical Center, University of California San Diego, Yale University, Harvard University, Massachusetts General Hospital, University of Louisville, National Institutes of Health, National Institute of Allergy and Infectious Diseases
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,763
OpenAlex ID: W7135168300