Incidence of azole resistance among clinical isolates of Candida parapsilosis: Results from the French nationwide multicenter prospective study “ReCap” 2022-2024
Year: 2026
Type: article
Study design: Observational Study
Abstract: Background: have emerged worldwide in recent years. Objective: Our objectives were to get an overview of the French epidemiology, to determine the incidence of azole resistance and to assess the genetic relationship between isolates. Methods: isolates routinely identified in 15 French hospital mycology laboratories were included over a period of 6 to 20 months (depending on the center), regardless of the type of specimen and hospitalization unit. Isolates were tested for fluconazole susceptibility using a gradient diffusion method. Non-susceptible isolates (MIC ≥4 mg/L) and a random selection of susceptible isolates were subjected to further analysis (MICs determination by EUCAST method and microsatellite genotyping). Results: Between May 2022 and February 2024, a total of 2,602 isolates were collected from 1,830 patients. Among these, 392 isolates (15.1%) from 184 patients (10%) were found to be resistant (MIC >4 mg/L). Percentage of patients colonized or infected by a resistant isolate ranged from 0 to 54.4% across centers. Genotyping analysis performed on 1,320 isolates showed high diversity among susceptible isolates and indicated that two fluconazole-resistant clusters are circulating in different hospitals of the Paris area. Cross-resistance occurred frequently with voriconazole resistance observed in 62.9% (73/116) of fluconazole-resistant isolates. Conclusion: , with very significant differences between regions. The Paris area is affected by two epidemic clusters involving many patients.
Source: New Microbes and New Infections
Authors: Arnaud Fekkar, Marion Blaize, Sophie Cassaing, Boualem Sendid, Grégoire Pasquier, Sébastien Imbert, Christophe Hennequin, Françoise Botterel, Florent Morio, Jean Menotti, Solène Le Gal, Eloise Bailly, Marie-Elisabeth Bougnoux, Antoine Huguenin, Christine Bonnal, Milène Sasso, Aliosha Feuss, Arnaud Jabet, Alexandre Godmer, Renaud Piarroux, Anne-Cécile Normand
Institutions: Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Centre Hospitalier Universitaire de Toulouse, Hôpital Purpan, Centre National de la Recherche Scientifique, Inserm, Université de Lille, Centre Hospitalier Universitaire de Lille, Université de Montpellier, Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle, Centre Hospitalier Universitaire de Montpellier, Institut de Recherche pour le Développement, Centre Hospitalier Universitaire de Bordeaux, Hôpital Saint-Antoine, Hôpitaux Universitaires Henri-Mondor, Centre Hospitalier Universitaire de Nantes, Cibles et Médicaments des Infections et de l'Immunité, Nantes Université, Lyon 1 Université, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université de Bretagne Occidentale, Centre Hospitalier Régional Universitaire de Brest, Université d'Angers, CHU Dijon Bourgogne, Hôpital Necker-Enfants Malades, Centre Hospitalier Universitaire de Reims, Hôpital Bichat-Claude-Bernard, Sorbonne Université, Centre d'Immunologie et des Maladies Infectieuses
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,770
OpenAlex ID: W7135198954