Efficacy and safety of finerenone in diabetic kidney disease: Latin American experience from FINDKDLATAM trial
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND Patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) face high renal and cardiovascular risks. Finerenone, a selective non-steroidal mineralocorticoid receptor antagonist, has demonstrated efficacy in reducing these risks in clinical trials. However, its real-world safety and effectiveness remain underexplored in local settings. AIM To evaluate the real-world safety and effectiveness of finerenone in patients with T2DM and CKD across seven Latin American countries. METHODS We conducted an observational, multicenter, retrospective cohort study based on real-world data in 347 patients with T2DM and CKD [urinary albumin-creatinine ratio (UACR) > 30 mg/g]. Patients received finerenone (10 mg or 20 mg daily), and clinical and laboratory parameters were evaluated at baseline and after six months of treatment. RESULTS At baseline, median values (interquartile range) were: Glycated hemoglobin A1c 7.6% (6.8%-8.1%); estimated glomerular filtration rate 39.0 mL/minute/1.73 m2 (30.0-50.0); UACR 345 mg/g (189-760); systolic blood pressure 143 mmHg (130-160); diastolic blood pressure 79 mmHg (70-82); and serum potassium 4.4 mmol/L (4.1-4.7). After six months, significant reductions were observed: Glycated hemoglobin A1c to 7.0% (6.5%-7.9%); UACR to 81 mg/g (28-167); systolic blood pressure to 130 mmHg (120-140); and diastolic blood pressure to 73 mmHg (70-80). Serum potassium increased to 4.7 mmol/L (4.3-5.0), while estimated glomerular filtration rate remained stable at 41.6 mL/minute/1.73 m2 (27.0-52.0). CONCLUSION In our cohort of patients with CKD associated with T2DM, finerenone proved to be an effective short-term therapy for reducing albuminuria, demonstrating very good tolerance and a low risk of hyperkalemia.
Source: World Journal of Nephrology
Authors: Rodrigo Daza Arnedo, Vicente Sánchez Polo, Jenniffer Benavides Garcia, Juan Felipe Gutiérrez, Enrique Ramos Clason, Daniel Domínguez, Giovany Mera Rebutti, Carlos Madrid Mancia, Rene Tabora López, Manuel Rocha Meza, Dany Tabora López, James J Muñoz Zambrano, Eduardo Lorca Herrera, Eliana Dina-Batlle, Michael Cieza Terrones, Thyago Proença de Moraes, Tomas Rodriguez Yánez, Washington Osorio, Alyi Arellano Cabeza, Jorge Rico-Fontalvo
Institutions: Asociación Colombiana de Nefrología e Hipertensión Arterial, Universidad de San Carlos de Guatemala, Universidad del Rosario, University of Cartagena, National Autonomous University of Honduras, Universidad Católica de Honduras Nuestra Señora Reina de la Paz, University of Chile, Universidad Peruana Cayetano Heredia, Pontifícia Universidade Católica do Paraná, Universidad del Valle, Universidad Simón Bolívar
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7135205687