Year: 2026
Type: article
Abstract: Continuous exposure to environmental stressors necessitates the development of novel, effective, and safe cosmetic active ingredients to preserve the skin’s structural integrity and physiological function. In this context, chiral cosmetic actives have emerged as particularly promising candidates owing to their diverse skincare properties. Notably, stereochemistry can markedly influence biological activity, producing enantiomer- or diastereomer-specific differences in efficacy and safety. Herein, we summarize recent advances in the application of chiral bioactive molecules as cosmetic actives, organizing them according to biological activity. We provide a comprehensive discussion of their mechanistic biological activities, the activity differences arising from distinct stereochemical configurations, current limitations, and future prospects.
Source: Cosmetics
Authors: Bingxue Liu, Xingting Fan, Jing Wang
Language: English
Topic: Skin Protection and Aging
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,172
OpenAlex ID: W7135213293