Work

Chemical Space Navigation of Nitidine Leads to the Discovery of a Novel PD-L1 Degradation Agent by Targeting CSN5 for Enhanced Antitumor Immunity

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03636

Authors: Qun Wang, Mengmeng Guo, Yujia Song, Kai Cui, Hongmei Hu, Xinying Xue, Dianping Yu, Hanchen Xu, Qing Zhang, Mengting Xu, Hanchi Xu, Linyang Li, Shize Xie, Mei Xie, Shuzhen Lyu, Yutong Xie, Sanhong Liu, Weidong Zhang, Jinxin Wang

Institutions: Shanghai University of Traditional Chinese Medicine, Second Military Medical University, Southern Medical University, Capital Medical University, Beijing Shijitan Hospital, Chinese PLA General Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Science and Technology Commission of Shanghai Municipality, Shanghai University of Traditional Chinese Medicine, National Key Research and Development Program of China

Awards: G1112760424, G1280314394, G1404677742, G5171731871, G6856432281, G7006314054, G7169906910, G7848332919

OpenAlex ID: W7135227259

FWCI: 5.557

Cites: 43

Cited by: 2

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