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Hyperhomocysteinemia and Ischemic Brain Injury: A Rare Case of Cystic Encephalomalacia in an Adult

Year: 2026

Type: article

Abstract: Cystic Encephalomalacia refers to the destruction of brain tissue following cerebral infarction and ischemia, infection, head trauma, or other injury. Cystic encephalomalacia (CE) is a most rare disease in adults. Though multiple causative factors come into play, hyperhomocysteinemia is now regarded as a potent aetiology. Here, we describe a 48-year-old male with previous history of cerebrovascular accident (CVA) who was admitted with multiple episodes of seizures. MRI showed chronic infarcts with cystic encephalomalacia changes, and metabolic screening demonstrated elevated levels of homocysteine. This is a case showing the significance of metabolic factors in ischemic cerebral injury and early screening. Differential diagnosis of CE from other changes due to ischemia is of paramount importance to ensure proper treatment and prognosis.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

DOI: 10.5281/zenodo.19004584

Authors: Suman, GR, Bhargave, KC, Reddy, Rashi P, Patil, Anjali C, Ajay, R

Institution: Shamnur Shivashankarappa Institute of Medical Sciences & Research Centre

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7135244238

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