Work

Gene-environment equivalence: The fundamental principle of Mendelian randomization

Year: 2026

Type: article

Abstract: The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers, and editors of gene-environment equivalence, the fundamental principle of MR.

Source: PLoS Medicine

DOI: 10.1371/journal.pmed.1005013

Authors: George Davey Smith, Gibran Hemani, Shah Ebrahim

Institutions: University of Bristol, MRC Integrative Epidemiology Unit, London School of Hygiene & Tropical Medicine

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $6,460

Funders: University of Bristol, Medical Research Council