Work

Scaffold Connectivity and Ear Cartilage Progenitor Cells’ Chondrogenic Potential Support a Tissue-Engineered Strategy for Pediatric Airway Repair

Year: 2025

Type: other

Abstract: Pediatric subglottic stenosis is a narrowing of the airway below the vocal folds due to prolonged intubation. Severe cases (>71% closure) often require laryngotracheal reconstruction (LTR). Current treatments use rib cartilage, which is limited in children and associated with donor site morbidity and restenosis. There is a need for a tissue-engineered LTR option that matches the size and clinical timeline of treatment. The goal is to produce tissue-engineered cartilage by seeding ear cartilage progenitor cells (eCPCs) onto a micro-structured polymeric scaffold. We show that the scaffold maintains high connectivity and that eCPCs exhibit robust chondrogenesis.

Source: ScholarlyCommons (University of Pennsylvania)

Authors: Son, Noah, Chen, Jeffrey F., Gottardi, Riccardo

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7135278451

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Related to: 10