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Acute metabolic and molecular responses to sprint interval versus moderate-intensity continuous exercise in healthy young men

Year: 2026

Type: article

Abstract: This study shows that a single bout of sprint interval exercise produces greater acute improvements in whole body and skeletal muscle insulin sensitivity than a much longer session of moderate-intensity continuous exercise, despite requiring far less total work and time. The findings highlight exercise intensity, not duration, as a key driver of rapid metabolic adaptations and identify sprint interval exercise as a highly time-efficient strategy for enhancing insulin sensitivity.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00548.2025

Authors: Enda Murphy, Claire Laurens, Laurie Frances, Marie-Adeline Marquès, François Crampes, Isabelle de Glisezinski, Javier Monedero, Helena Kenny, Noel McCaffrey, Francis M. Finucane, Cedric Moro, Donal O'Gorman

Institutions: Ollscoil na Gaillimhe – University of Galway, Inserm, Institut des Maladies Métaboliques et Cardiovasculaires, Technological University Dublin, Dublin City University

Language: English

Topic: Cardiovascular and exercise physiology

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Boehringer Ingelheim, Science Foundation Ireland, European Foundation for the Study of Diabetes, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale, Research Ireland

Awards: G1359624113, G1495910769, G1517072726, Muscle, Adipose and Pancreatic Islet Crosstalk in the Pathogenesis of Type 2 Diabetes, Timing of eating and exercise as a novel strategy to preserve muscle mass and improve glycemic control in obese post-menopausal women with type 2 diabetes, G5741847476

OpenAlex ID: W7135369348

FWCI:

Cites: 25

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