Reproducibility of a time-resolved NIRS, multidistance diffuse correlation spectroscopy system: towards noninvasive longitudinal neuromonitoring
Year: 2026
Type: article
Abstract: SignificanceLongitudinal monitoring of cerebral blood flow (CBF), oxygenation (StO2), and cerebral metabolic rate of oxygen (CMRO2) could allow for early detection of secondary brain injury before clinical signs manifest.AimReproducibility and reliability of an in-house time-resolved near-infrared spectroscopy (trNIRS)/multidistance diffuse correlation spectroscopy (mdDCS) system were assessed to determine the feasibility of daily monitoring. In addition, carotid compression was performed to demonstrate longitudinal monitoring.ApproachTime-resolved NIRS/mdDCS measurements were acquired daily on volunteers across one week. Reproducibility was quantified by the coefficient of variation (CV) and reliability by the intraclass correlation coefficient (ICC) at three levels: within-acquisition, between-acquisition, and between-day. A subset of participants returned on day 21+, and carotid compression was performed to reduce CBF. Signal changes during compression were compared to baseline measurements from that day and previous days.ResultsAll optical measurements showed good-to-excellent within-acquisition, between-acquisition, and between-day reproducibility (CV<19%) and reliability (ICC between 0.67 and 0.99), except short-distance DCS, which was sensitive to probe repositioning. Reductions in CBF, StO2, and CMRO2 caused by carotid compression were similar in magnitude when using same-day baseline to baseline values up to three weeks prior.ConclusionsThis study demonstrates the feasibility of daily monitoring using a hybrid trNIRS/mdDCS system.
Source: Neurophotonics
Institution: Western University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,675
OpenAlex ID: W7135395474
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