Work

Effects of proANP 31–67 in a preclinical model of uninephrectomy and cardiac ischemia/reperfusion injury: cardiac remodeling and tissue biochemical profiling

Year: 2026

Type: article

Abstract: In a model of reduced nephron mass combined with cardiac ischemia/reperfusion injury, proANP 31–67 prevented adverse cardiac remodeling independent of blood pressure. Vibrational spectroscopy identified coordinated biochemical alterations in cardiac and renal tissues not detected by conventional assays, providing molecular-level insight into cardiorenal remodeling.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00339.2025

Authors: Gustavo Jose Justo Silva, Sara Stefani, Reza Parvan, Michael Frisk, Xin Shen, Martina Alunni Cardinali, Mari E. Strand, Karoline Bjarnesdatter Rypdal, Mathis Korseberg Stokke, Håvard Attramadal, Ida G. Lunde, Jan Magnus Aronsen, Kåre-Olav Stensløkken, William E. Louch, Paola Sassi, Alessandro Cataliotti

Institutions: Oslo University Hospital, University of Oslo, University of Perugia, University of Auckland

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Norges Forskningsråd, Nasjonalforeningen for Folkehelsen, Helse Sør-Øst RHF, NextGenerationEU

Awards: G1368654211, G1767833581, G2301263912, G3320147224, G4312459242, G4637308113, G4904659416, G492615786, G5195752625, G8609174333

OpenAlex ID: W7135402030

FWCI: 9.395

Cites: 56

Cited by: 2

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