Year: 2026
Type: review
Study design: Systematic Review
Abstract: Background and Aims: This systematic review evaluates the benefits of secretome application in ligament healing. Materials and Methods: Secretome treatment is shown to enhance graft revascularization, collagen deposition, and biomechanical strength in preclinical investigations. Clinical investigations indicated improved functional recovery, diminished inflammation, and decreased graft failure rates relative to traditional anterior cruciate ligament (ACL) reconstruction. Nevertheless, variability in secretome preparation and application techniques restricts direct comparisons. Results: The comprehensive review consolidates findings from qualifying investigations, emphasizing enhancements in collagen organization, vascularization, biomechanical strength, and clinical functional scores. Variations in the source, dosage, and application method of the secretome affected the outcomes. Conclusion: Secretome treatment seems to improve ACL autograft healing by facilitating biological integration and functional recovery. Although pre-clinical and initial clinical findings are encouraging, additional high-quality randomized controlled studies are essential to establish standardized techniques and validate long-term efficacy.
Institution: Udayana University
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7135404167