Additional file 5: Figure S4. of Novel Plasmodium falciparum metabolic network reconstruction identifies shifts associated with clinical antimalarial resistance
Year: 2017
Type: article
Abstract: Artemisinin sensitive and resistant parasites utilize different metabolic genes and pathways. Enrichment analysis of gene utilization in sensitive and resistant parasite models demonstrates functional differences in expression data integration. Consensus gene utilization from resistant and sensitive models (both Cambodian and Vietnamese datasets) were used and compared to unconstrained model. Black = p < 0.001, grey = p < 0.01, light grey = p < 0.05, white = non significant. Abbreviation key: Aminosugars = amino sugar metabolism; ArgPro = arginine and proline metabolism; AsnAsp = asparagine and aspartate metabolism; BiosynthesisCytochrome = biosynthesis of cytochromes; CoABiosynthesis = coenzyme-A biosynthesis; Dolichol = dolichol metabolism; Exchange = exchange reactions; FattyAcidSynthesis = fatty acid synthesis; FolateBiosynthesis = folate biosynthesis; Glu = glutamate metabolism; Glycolysis = glycolysis; GlySer = glycine and serine metabolism; GPIAnchorBiosynthesis = GPI anchor biosynthesis; Hemoglobin = hemoglobin degradation (including hemozoin formation); InositolPhosphate = inositol phosphate metabolism; Isoprenoids = isoprenoid metabolism; LeuIleVal = leucine, isoleucine, and valine metabolism; Lys = lysine metabolism; MannoseFructose = mannose and fructose metabolism; MetPolyamine = methionine and polyamine metabolism; MitochondrialElectronFlow = mitochondrial electron transport chain; MitochondrialTCACycle = mitochondrial tricarboxylic acid cycle; NicotinateNicotinamide = nicotinate and nicotinamide metabolism; Nitrogen = nitrogen metabolism; PentosePhosphateCycle = pentose phosphate cycle; PheTyr = phenylalanine and tyrosine metabolism; Phosphatidylcholine = phosphatidylcholine metabolism; PhosphatidyletanolaminePhosphatidylserine = phosphatidyletanolamine and phosphatidylserine metabolism; Porphyrin = porphyrin metabolism; Propionate = propionate metabolism; Purine = purine metabolism; Pyrimidine = pyrimidine metabolism; Pyruvate = pyruvate metabolism; Redox = redox metabolism; RedoxMitochondrialAntioxidantSystem = mitochondrial redox metabolism; Riboflavin = riboflavin (vitamin B2) metabolism; Selenocysteine = selenocysteine metabolism; ShikimateBiosynthesis = shikimate biosynthesis; SphingomyelinCeramide = sphingomyelin and ceramide metabolism; Terpenoid = terpenoid metabolism; Thiamine = thiamine biosynthesis; Transport = transport reactions; tRNA = tRNA and protein synthesis; Trp = tryptophan metabolism; Ubiquinone = ubiquinone metabolism; UtilizationPhospholipids = utilization of phospholipids; VitB6 = pyridoxal (vitamin B6) metabolism. (PDF 6 kb)
Source: Figshare
Authors: Carey, Maureen, Papin, Jason, Guler, Jennifer
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7136033275