Additional file 3: Figure S2. of Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling
Year: 2017
Type: article
Abstract: Showing that Emab does not affect the expression of BCR inducible genes and genes associated with TLR signaling. Tonsillar CD10–CD27– B cells were negatively selected using magnetic bead cell separation and then stimulated with R848 (TLR7 agonist) and/or anti-human F(ab′)2 IgM with or without Emab or a human IgG control. RNA was isolated 12 hours after stimulation and expression of different genes was quantified by RT-PCR. Graphs show combined data of three independent experiments, presented as mean ± SD. (PDF 41 kb)
Source: Figshare
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7136063776