Work

Additional file 11: Figure S8. of Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

Year: 2016

Type: article

Abstract: Time dependent combination effect of dactolisib and trametinib in DU4475 and MDA-MB-231 cell lines. Each matrix represents toxicity based delta score combination plot (red being synergistic and green being antagonistic). The toxicity readout was measured after 96 h from onset of screen disregarding different subsequent combination of drugs in different times to monitor (A) both drugs added together at 0 h, (B) dactolisib added at the onset of experiment and then trametinib combined after 24 h, (C) dactolisib added at the onset of experiment and then trametinib combined after 48 h. (PDF 145 kb)

Source: Figshare

DOI: 10.6084/m9.figshare.4673002

Authors: Gautam, Prson, Karhinen, Leena, Szwajda, Agnieszka, Jha, Sawan Kumar, Yadav, Bhagwan, Aittokallio, Tero, Wennerberg, Krister

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7136074061

FWCI:

Cites:

Cited by:

Related to: 10