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Additional file 3: Figure S1. of Dioxins and related environmental contaminants increase TDP-43 levels

Year: 2017

Type: article

Abstract: Elevation of endogenous TDP-43 is dependent upon AHR expression. Figure S2. The effect on TDP-43 protein levels in the brain of peripheral exposure to AHR agonists is not observed with other disease related proteins. Figure S3. TARDBP promoter is activated by AHR agonism. Figure S4. Click-iT pulse-chase labelling of nascent proteins in differentiated M17 cells. Figure S5. Schematic representation of sense AHRE consensus sites â GCGTGâ (red flags) of human CYP1A1 and CYP1B1 AHR responsive genes and the ALS-relevant genes TARDBP, SOD1, PON2, C9ORF72, FUS and ATXN2, assayed for changes in transcript levels in Fig. 2. Green boxes are exons. (PDF 2754 kb)

Source: Figshare

DOI: 10.6084/m9.figshare.4980953

Authors: Ash, Peter, Stanford, Elizabeth, Al Abdulatif, Ali, Ramirez-Cardenas, Alejandra, Ballance, Heather, Boudeau, Samantha, Jeh, Amanda, Murithi, James, Tripodis, Yorghos, Murphy, George, Sherr, David, Wolozin, Benjamin

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7136050336

FWCI:

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