Additional file 2: Figure S2. of Single-cell epigenomic variability reveals functional cancer heterogeneity
Year: 2017
Type: article
Abstract: Molecular characteristics of identified subpopulations. a Heatmap of the correlation coefficient of K562 CD24 sorted ATAC-seq samples using Spearman correlation. b UCSC tracks showing examples of open chromatin in CD24lo (blue) and CD24hi (red) K562 cells. Top: JUN locus, which is more accessible in CD24lo. Bottom: SOD1 locus, which is equally accessible in both subpopulations. c Bar plot illustrating the distribution of ATAC-seq peaks across genomic locations; promoter proximal (light blue) and distal (dark blue). The difference in promoter accessibility between CD24hi and CD24lo K562 cells is significant (using Chi-squared), p < 0.001. d Gene Ontology terms for accessible chromatin locations in CD24lo cells. e Q-Q plot illustrating the differences in the overlap of ENCODE DNAse-seq peaks and ATAC-seq peaks of CD24lo and CD24hi populations (shown in Fig. 2g). P values for Wilcox (WX), t-test (TT), and Komorov–Smirnov (KS). f Enrichment of GATA2 ChIP-seq binding sites in CD24hi and CD24lo K562 ATAC-seq peaks. (PDF 507 kb)
Source: Figshare
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7136058461