Additional file 4: Figure S3. of Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling
Year: 2017
Type: article
Abstract: Showing that IFN-α priming increases TLR7 expression and promotes IL-10 production, which is further enhanced in the presence of Emab. (A) Tonsillar CD10–CD27– B cells were stimulated with IFN-α (100 U/ml) for 3–12 hours. Increase of TLR7 levels presented as fold increase relative to unstimulated cells at 3 hours. (B) Cells were left untreated or IFN-α-primed for 6 hours, and then stimulated with R848 and/or F(ab′)2 anti-human IgM with or without Emab or a human IgG control. Graphs show the levels of IL-10 production after 3 days of cell culture. Data shown are representative of three independent experiments with similar results. (PDF 27 kb)
Source: Figshare
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7136070013