Additional file 5: Figure S4. of WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines
Year: 2016
Type: article
Abstract: ER regulation of WNT4 and potential interaction with PR at binding sites near the WNT4 gene locus. a MM330 cells were hormone-deprived as described in Materials and Methods and treated with 1 nM E2 ± 1 μM ICI for 24 h. Bars represent biological triplicate ± SD. *p < 0.05 by one-way analysis of variance vs respective control with Dunnett’s multiple comparisons test. b Data derived from the study by Mohammed et al. [27] [GEO:GSE68355]. Model-based analysis of ChIP-Seq (MACS) peaks were visualized using the Integrated Genomics Viewer browser (Broad Institute, Cambridge, MA, USA), and aligned the RefSeq gene set in hg19. Dashed green box is an enlargement showing binding sites proximal to the WNT4 ERBS in MM134 and the WNT4 transcriptional start site. Dashed blue box shows an upstream region (−30 kb) of P4-induced ER/PR binding in MCF-7. c Samples were treated and ChIP-qPCR performed as described in Fig. 2 legend. IgG Immunoglobulin G. (PDF 175 kb)
Source: Figshare
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7136118676
FWCI:
Cites:
Cited by:
Related to: