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Additional file 6: of miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

Year: 2016

Type: article

Abstract: A combination of miR-27a and miR-27b does not further inhibit PINK1 expression compared to each miRNA alone. HeLa cells were transfected with 80 nM negative control (Ctl), 40 nM Ctl with 40 nM miR-27a (miR-27a), 40 nM Ctl with 40 nM miR-27b (miR-27b), or 40 nM miR-27a with 40 nM miR-27b (miR-27a/b). 48 h post-transfection, PINK1 levels were measured by Western blot and normalized to corresponding GAPDH levels. Data are shown as a percentage of control (n = 4, one-way ANOVA). Values are mean ± SEM (***p < 0.001). (PDF 42 kb)

Source: Figshare

DOI: 10.6084/m9.figshare.4425143

Authors: Kim, Jaekwang, Fiesel, Fabienne, Belmonte, Krystal, Hudec, Roman, Wang, Wang-Xia, Kim, Chaeyoung, Nelson, Peter, Springer, Wolfdieter, Kim, Jungsu

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7136126776

FWCI:

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