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Synchronous activation of striatal cholinergic interneurons induces local serotonin release

Year: 2026

Type: article

Abstract: Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.

Source: Nature Communications

DOI: 10.1038/s41467-026-70359-6

Authors: Lior Matityahu, Zachary B. Hobel, Noa Berkowitz, Jeffrey M. Malgady, Naomi Gilin, Joshua L. Plotkin, Joshua A. Goldberg

Institutions: Hebrew University of Jerusalem, Stony Brook University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990

Funders: United States - Israel Binational Science Foundation, Israel Science Foundation, National Institutes of Health, John W. Hartman Center, Duke University, National Institute of Neurological Disorders and Stroke

Awards: G1387283186, G3603083090, G7922207141, Direct amygdala modulation of the dorsolateral striatum and compulsive behaviors

OpenAlex ID: W7136149824

FWCI: 9.448

Cites: 67

Cited by: 4

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