Establishment of CSUASOi014-A, an induced pluripotent stem cell line from blood-derived cells of a Chinese patient carrying PRPF31 gene mutation
Year: 2026
Type: article
Abstract: Retinitis pigmentosa (RP) is a group of inherited retinal degenerative disorders characterized by progressive visual dysfunction. In this study, we generated an induced pluripotent stem cell (iPSC) line, CSUASOi014-A, from peripheral blood cells of a 40-year-old Chinese female patient clinically diagnosed with RP. Peripheral blood mononuclear cells were isolated and reprogrammed using an integration-free Sendai virus system. The established iPSC line harbors a heterozygous PRPF31 c.528-39_531del mutation. CSUASOi014-A provides a patient-specific cellular resource for studying the pathogenic mechanisms underlying PRPF31-associated RP.
Source: Stem Cell Research
Authors: Yuan Liang, Xihao Sun, Yuqin Liang, Hang Chen, Chunwen Duan, Yuexi Chen, Wenwei Li, Jianing Gu, Zekai Cui, Chengcheng Ding, Jiansu Chen
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,360
OpenAlex ID: W7136166902