Work

Evidence of histamine release in response to both aerobic and resistance exercise: histamine metabolites as biomarkers

Year: 2026

Type: article

Abstract: Histamine released from muscle increases blood flow and facilitates adaptation to exercise training. However, tracking the histamine response to exercise has been challenging because of its short half-life. We show that production of both 1-methylhistamine and 1-methylimidazole acetic acid, metabolites of histamine, increases with exercise. This provides a novel means to detect the histamine response to multiple forms of exercise, based on the appearance of histamine metabolites in the circulation or captured in urine.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.01166.2025

Authors: Brandon M. Gibson, Kieran S. S. Abbotts, Hope F. Cursetjee, Karen Wiedenfeld Needham, Christopher T. Minson, John R. Halliwill

Institution: University of Oregon

Language: English

Topic: Exercise and Physiological Responses

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Oregon Foundation, National Institutes of Health, National Institute on Aging