Year: 2026
Type: article
Abstract: Self-replicating RNA vaccines delivered by viral replicon particles (VRPs) induce strong immunity, but repeated dosing on short intervals may be limited by vector responses. In patient samples and mice, VRP-srRNA vaccination generated VRP-neutralizing antibodies and T-cell responses to replicase. In mice, a third dose at two-week intervals minimally boosted transgene immunity, and prior VRP exposure reduced responses to a different-transgene VRP. Optimized schedules or heterologous prime-boost may sustain immunogenicity.
Source: npj Vaccines
Institution: Duke University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,890
Awards: MECHANISM OF CMV VACCINE VECTORS THERAPEUTIC EFFICACY IN A SPONTANEOUS MODEL OF MAMMARY CANCER, THERAPEUTIC TARGETING OF BREAST CANCER AND HOST IMMUNE RESPONSES AT INFLECTION POINTS IN THE DISEASE TRAJECTORY, G3865632432, Viral Oncology Training Grant, G4119534169, G4312584767, G5850682332, G7448966117, Enabling effective anti-tumor immunity from targeted antibodies through dual innate and adaptive immune checkpoint blockade in non-immunogenic cancers, G9000243897, G9000305293
OpenAlex ID: W7136182983