Work

Immunoproliferative small intestinal disease presenting as gastrointestinal bleed

Year: 2026

Type: article

Abstract: Immunoproliferative small intestinal disease (IPSID) also called “Mediterranean lymphoma”, is a rare variant of mucosa-associated lymphoid tissue (MALT) lymphomas mainly involving the proximal small intestine. IPSID typically presents with nonspecific GI symptoms including chronic diarrhea, weight loss and malabsorption which typically delay diagnosis. This entity rarely presents as gastrointestinal (GI) bleed; we report a rare case of IPSID presenting as iron deficiency anemia and melena as a consequence of bleeding from the small intestine which was eventually diagnosed on capsule endoscopy after normal initial gastroscopy and colonoscopy. The patient received six courses of chemotherapy with a combination of rituximab and bendamustine, with good outcomes at 6 months post therapy completion.

Source: Medical Reports

DOI: 10.1016/j.hmedic.2026.100434

Authors: Johny Salem, Gilles Saleh, Mohamad Wehbeh, Noha Al-Hachem

Institution: University of Balamand

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,900