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Cardiorespiratory fitness attenuates the association between psychosocial stress and cardiometabolic risk – Results from the SCAPIS population

Year: 2026

Type: article

Abstract: AIMS: Low cardiorespiratory fitness (CRF) and high psychosocial stress can contribute to cardiovascular disease. CRF is a strong predictor of cardiovascular outcomes, yet population-based evidence on whether CRF buffers stress-related risk remains limited. This study aims to (1) examine associations between CRF, stress, and cardiometabolic risk; (2) assess whether CRF moderates the relationship between stress and cardiometabolic risk; and (3) explore whether associations between CRF and cardiometabolic risk are stronger among high-stress individuals. METHODS: We included 4,207 healthy, middle-aged participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS), conducted 2013-2018. CRF was estimated using submaximal cycle testing (ml/min/kg). Perceived psychosocial stress was measured using a single self-reported item dichotomised into "low" and "high". Ten cardiometabolic outcomes were assessed, including waist circumference, BMI, and blood pressure. Cross-sectional associations were analysed in R, using t-tests and multiple linear regression. RESULTS: Individuals reporting high stress had lower CRF (-1.7 ml/min/kg, p < .001) and less favourable cardiometabolic profiles. CRF moderated the relationship between stress and waist circumference, BMI, systolic- and diastolic blood pressure. For each 1 ml/min/kg higher CRF, the stress-related association was reduced by 0.17 cm in waist circumference (p < .001), 0.06 kg/m2 in BMI (p < .001), 0.18 mmHg in systolic blood pressure (p = .030), and 0.13 mmHg in diastolic blood pressure (p = .020). Associations were 13-25% stronger in the high-stress group. CONCLUSION: Higher CRF attenuated the association between psychosocial stress and cardiometabolic risk. Promoting physical activity to improve CRF could be important during periods of high stress to counteract stress-related cardiometabolic deterioration.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0345029

Authors: Frida Griffin, Jonatan Fridolfsson, Daniel Arvidsson, Ingibjörg H. Jonsdottir, Mats Börjesson

Institutions: University of Gothenburg, Sahlgrenska University Hospital, Region Västra Götaland

Language: English

Topic: Physical Activity and Health

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382