Work

Computational prospection of functional peptides from kefir microbiota with multitarget potential in Alzheimer’s disease

Year: 2026

Type: article

Abstract: Alzheimer’s disease (AD) involves the accumulation of β-amyloid (Aβ), synaptic dysfunction, and neuronal loss. Given the limited efficacy of current treatments, natural bioactive molecules, such as peptides derived from kefir microbiota, are gaining interest. In silico analyses of two peptides from Brazilian kefir were carried out to assess their potential against key AD targets (Aβ, BACE1, and AChE). Docking studies showed that both peptides bind to fibrillar and monomeric Aβ, suggesting a possible preventive effect on aggregate formation. PepKLacM01 exhibited stronger binding to BACE1 and AChE, indicating potential inhibition, whereas PepKLacM02 displayed weaker and more peripheral interactions, yet maintained modulatory effects on Aβ aggregation. These findings suggest complementary mechanisms of action—aggregation prevention, enzyme inhibition, and modulation—and support further experimental validation for their potential therapeutic application in AD.

Source: International Journal of Food Science & Technology

DOI: 10.1093/ijfood/vvag033

Authors: Samuel Henrique Pereira Fonseca, Ana Carolina Costa Santos, Matheus Henrique Silva, Serena Mares Malta, Carlos Ueira-Vieira

Institution: Universidade Federal de Uberlândia

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,638