The role of new generation inflammatory markers in patients undergoing carotid endarterectomy
Year: 2026
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: This study aimed to evaluate the prognostic value of novel systemic inflammatory markers, particularly the Systemic Immune-Inflammation Index (SII), in predicting morbidity and mortality in patients undergoing carotid endarterectomy. METHODS: A retrospective analysis was conducted on 200 patients who underwent carotid endarterectomy. Patients were categorized into two groups based on their 1-year postoperative survival status (group-1:alive, group-2: dead). Inflammatory parameters including SII, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR)were calculated. Demographic, clinical, echocardiographic, and angiographic data were analyzed. The association between inflammatory markers and outcomes was assessed using univariate and multivariate analyses. RESULTS: SII, NLR and PLR were significantly higher in the group-2 (p < 0.001). Patients with internal carotid artery tortuosity exhibited longer operation times (p = 0.002), and those with elevated SII levels had a higher risk of adverse outcomes. No significant difference was observed in echocardiographic parameters between the two groups. The presence of comorbidities such as hyperlipidemia and coronary artery disease was also more prevalent in the group-2. CONCLUSION: Systemic inflammatory markers, particularly SII, may serve as useful predictors of postoperative mortality and procedural complexity in patients undergoing carotid endarterectomy. Incorporating these markers into preoperative risk assessment may improve clinical decision-making and patient outcomes.
Source: BMC Surgery
Authors: Fehim Can Sevil, Halil Siner, Cem Korucu, Uğur Aksu
Institution: Afyonkarahisar Sağlık Bilimleri Üniversitesi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,090
OpenAlex ID: W7136229089