Mechanochemical synthesis of carboxylic acids and amides: Nickel-catalyzed direct carbonylation of aryl halides using dry ice
Year: 2026
Type: article
Abstract: Carboxylic acids and their derivatives have great importance in synthetic organic chemistry. The development of an eco-friendly and efficient approaches for the synthesis of carboxylic acid derivatives using readily available gaseous CO 2 as a C1 synthon is still a very challenging task. Herein, we report a convenient mechanochemical approach for the direct transformation of aryl halides into carboxylic acids/amides using dry ice as a CO 2 source in the presence of nickel as a catalyst, nanocellulose as an additive, and iron powder as a reducing agent. The present dehalogenative ipso -carbonylation protocol features several advantages, such as the use of dry ice as a readily available C1 source, nanocellulose as a biodegradable additive, excellent yields under mild, solvent-free conditions, and easy separation/purification procedures.
Source: Journal of CO2 Utilization
Institutions: Matej Bel University, Pondicherry University, Charotar University of Science and Technology, Comenius University Bratislava, TU Wien, National Academy of Sciences of Ukraine, Institute of Organic Chemistry, Aarhus University, University of Bern, Georgian American University, Chitkara University
Language: English
Subfield: Process Chemistry and Technology
Field: Chemical Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,360
OpenAlex ID: W7136300614