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Additional file 1: of Feedback activation of neurofibromin terminates growth factor-induced Ras activation

Year: 2016

Type: article

Abstract: EGF-induced electrophoretic mobility shift of Sos is sensitive to MEK (10 μM UO126) and Erk (50 μM FR180204) but not Rsk (10 μM BI-D1870) or PI3K (100nM Wortmannin) inhibition. HeLa cells pre-treated with the indicated inhibitors or subjected to siRNA-mediated knockdown of neurofibromin (siNF1) were deprived of serum overnight and challenged 30 min with EGF. Lysates were processed for immunodetection of Sos, Rsk1/2/3 and Erk. (PDF 598 kb)

Source: Figshare

DOI: 10.6084/m9.figshare.4465688

Authors: Hennig, Anne, Markwart, Robby, Wolff, Katharina, Schubert, Katja, Cui, Yan, Prior, Ian, Esparza-Franco, Manuel, Ladds, Graham, Rubio, Ignacio

Language: English

Topic: Neurofibromatosis and Schwannoma Cases

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7136930792

FWCI:

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