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Data Driven discovery of A Stable Transdiagnostic Axis of Reward and Affective Regulatory Instability in Neuropsychopathology

Year: 2026

Type: preprint

Abstract: Psychiatric disorders are traditionally defined using categorical diagnoses, despite growing evidence that symptoms span continuous and overlapping dimensions. However, the mechanistic interpretation of transdiagnostic dimensions remains unclear. Emerging computational frameworks suggest that global psychopathology may reflect instability in hierarchical systems that regulate reward sensitivity, affective salience, and adaptive behavior rather than simple accumulation of symptoms.

DOI: 10.17605/osf.io/t3z54

Authors: Mahsa Asadi Anar, seyed kiarash sadat rafiei, Peren Jerfi Canatalay, Kimia Omidvar, Sasan Ghazanfari Ahari, Sepita Taghizadeh, Parsa Mostaghimi Motlagh, Nooshin Farrokhi, Parham Mahmoudi, Seyed Javad Jafari

Language: English

Topic: Mental Health Research Topics

Subfield: Experimental and Cognitive Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7137241962

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