Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
Year: 2025
Type: review
Abstract: Background: Early-life respiratory tract infections might affect chronic obstructive respiratory diseases, but conclusive studies from general populations are lacking. Our objective was to examine if children with early-life respiratory tract infections had increased risks of lower lung function and asthma at school age. Methods: We used individual participant data of 150 090 children primarily from the EU Child Cohort Network to examine the associations of upper and lower respiratory tract infections from age 6 months to 5 years with forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, forced expiratory flow at 75% of FVC (FEF75%) and asthma at a median (range) age of 7 (4-15) years. Results: Children with early-life lower, not upper, respiratory tract infections had a lower school-age FEV1, FEV1/FVC and FEF75% (z-score range: -0.09 (95% CI -0.14- -0.04) to -0.30 (95% CI -0.36- -0.24)). Children with early-life lower respiratory tract infections had a higher increased risk of school-age asthma than those with upper respiratory tract infections (OR range: 2.10 (95% CI 1.98-2.22) to 6.30 (95% CI 5.64-7.04) and 1.25 (95% CI 1.18-1.32) to 1.55 (95% CI 1.47-1.65), respectively). Adjustment for preceding respiratory tract infections slightly decreased the strength of the effects. Observed associations were similar for those with and without early-life wheezing as a proxy for early-life asthma. Conclusions: Our findings suggest that early-life respiratory tract infections affect development of chronic obstructive respiratory diseases in later life, with the strongest effects for lower respiratory tract infections.
Source: UTUPub (University of Turku)
Authors: van Meel Evelien R., Mensink-Bout Sara M., den Dekker Herman T., Ahluwalia Tarunveer S., Annesi-Maesano Isabella, Arshad Syed Hasan, Baïz Nour, Barros Henrique, von Berg Andrea, Bisgaard Hans, Bønnelykke Klaus, Carlsson Christian J., Casas Maribel, Chatzi Leda, Chevrier Cecile, Dalmeijer Geertje, Dezateux Carol, Duchen Karel, Eggesbø Merete, van der Ent Cornelis, Fantini Maria, Flexeder Claudia, Frey Urs, Forastiere Fransesco, Gehring Ulrike, Gori Davide, Granell Raquel, Griffiths Lucy J., Inskip Hazel, Jerzynska Joanna, Karvonen Anne M., Keil Thomas, Kelleher Cecily, Kogevinas Manolis, Koppen Gudrun, Kuehni Claudia E., Lambrechts Nathalie, Lau Susanne, Lehmann Irina, Ludvigsson Johnny, Magnus Maria Christine, Mélen Erik, Mehegan John, Mommers Monique, Andersen Anne-Marie Nybo, Nystad Wenche, Pedersen Eva S.L., Pekkanen Juha, Peltola Ville, Pike Katharine C., de Moira Angela Pinot, Pizzi Costanza, Polanska Kinga, Popovic Maja, Porta Daniela, Roberts Graham, Santos Ana Cristina, Schultz Erica S., Standl Marie, Sunyer Jordi, Thijs Carel, Toivonen Laura, Uphoff Eleonora, Usemann Jakob, Vafeidi Marina, Wright John, de Jongste Johan C., Jaddoe Vincent W.V., Duijts Liesbeth
Institutions: Erasmus MC, University of Copenhagen, Gentofte Hospital, Copenhagen Prospective Studies on Asthma in Childhood, Steno Diabetes Center Copenhagen, Inserm, Sorbonne Université, Institut Pierre Louis d‘Épidémiologie et de Santé Publique, Universidade do Porto, Instituto de Saúde, Marien Hospital Wesel, University of Southern California, Institut de Recherche en Santé, Environnement et Travail, Université de Rennes, Utrecht University, University Medical Center Utrecht, Queen Mary University of London, Linköping University, Norwegian Institute of Public Health, Wilhelmina Children's Hospital, University of Bologna, Helmholtz Munich, University of Basel, University Children’s Hospital Basel, Regione Lazio, University of Bristol, Swansea University, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Respiratory Biomedical Research Unit, MRC Lifecourse Epidemiology Unit, University of Southampton, Nofer Institute of Occupational Medicine, Finnish Institute for Health and Welfare, University College Dublin, University of Würzburg, Hospital del Mar Research Institute, Flemish Institute for Technological Research, Charité – Universitätsmedizin Berlin, Universitat Pompeu Fabra, Barcelona Institute for Global Health, Maastricht University Medical Centre, Care and Public Health Research Institute, University of Helsinki, University of Turku, Turku University Hospital, Bristol Royal Hospital for Children, University of Turin, Bradford Institute for Health Research, University of Crete
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, March of Dimes Foundation, GlaxoSmithKline, Compagnia di San Paolo, Strategiske Forskningsråd, Fundación Alicia Koplowitz, Universität Basel, Sundhed og Sygdom, Det Frie Forskningsråd, Fundació la Marató de TV3, Wellcome Trust, Health Research Board, Forskningsrådet i Sydöstra Sverige, Innovationsfonden, Government of the United Kingdom, Centres de Recerca de Catalunya, National Institute for Health and Care Research, British Heart Foundation, Asthma and Lung UK, British Medical Association, European Commission, University of Bristol, National Research Foundation, Science Foundation Ireland, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Danmarks Grundforskningsfond, ZonMw, Erasmus Universiteit Rotterdam, Universiteit Maastricht, Forskningsrådet för Arbetsliv och Socialvetenskap, Academy of Finland, Bundesministerium für Bildung und Forschung, Generalitat de Catalunya, Fondation pour la Recherche Médicale, Eusko Jaurlaritza, Suomen Kulttuurirahasto, Ministero della Salute, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Generalitat Valenciana, Helse- og Omsorgsdepartementet, Lundbeckfonden, Juho Vainion Säätiö, Karolinska Institutet, Novo Nordisk, Päivikki ja Sakari Sohlbergin Säätiö, Vetenskapsrådet, Fondation de France, Narodowym Centrum Nauki, Helmholtz-Zentrum für Umweltforschung, Nordea-fonden, Danmarks Frie Forskningsfond, Barndiabetesfonden, Norges Forskningsråd, Turun Yliopisto, Ludwig-Maximilians-Universität München, Lastentautien Tutkimussäätiö, Universidade do Porto, Université Paris-Sud, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, Mutuelle Générale de l'Education Nationale, Novo Nordisk Fonden, Egmont Fonden, Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, Turun Yliopistollinen Keskussairaala, Vlaamse regering, H. Lundbeck A/S, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Institut pour la Recherche en Santé Publique, National Institute for Health Research Southampton Biomedical Research Centre, Schweizerische Lungenstiftung, National Institutes of Health, Medical Research Council, Economic and Social Research Council, Leibniz-Gemeinschaft, Fundação para a Ciência e a Tecnologia, Instituto de Salud Carlos III, Programme Grants for Applied Research, European Regional Development Fund, Helmholtz Zentrum München, National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences, European Social Fund, H2020 European Research Council, CHIST-ERA
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