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The Role of NRF2 Transcription Factor

Year: 2024

Type: article

Abstract: The regulation of the transcription factor NRF2 opens a therapeutic window for a host of chronic degenerative diseases, such as diabetes and its complications, cancer, obesity, neurodegenerative diseases, kidney diseases, immunological diseases, and so on. The ability to regulate cytoprotective functions such as antioxidant defenses or pro-apoptotic or anti-apoptotic functions is of utmost importance. Currently, there are therapeutic agents to activate or inhibit NRF2; research should focus on understanding how NRF2 makes “the decision” to perform one function or another.

Source: Directory of Open access Books (OAPEN Foundation)

Authors: José Antonio Morales-Gonzalez, Eduardo Osiris Madrigal-Santillan, Marvin A. Soriano-Ursúa, Ángel Morales-González

Institutions: Universidad Nacional Autónoma de México, Instituto Politécnico Nacional

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Instituto Politécnico Nacional, Directorate for Biological Sciences, Sistema Nacional de Investigadores

OpenAlex ID: W7137633264