Work

Equivalent cumulative energy yields unequal lung injury: effects of tidal volume and ventilation duration in experimental lung injury

Year: 2026

Type: article

Abstract: This study reveals that the timing of energy delivery, not just its magnitude, determines ventilator-induced lung injury in endotoxin-induced lung damage. Using a rat model, high tidal volumes delivered over short periods caused disproportionate overdistension, edema, and inflammation compared with lower tidal volumes over longer periods, despite equivalent cumulative energy. These findings challenge the conventional focus on total ventilatory energy and highlight the need for strategies that account for temporal distribution to optimize lung protection.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.01207.2025

Authors: Raquel Ferreira De Magalhães, Adriana Lopes da Silva Vilardo, Pedro Henrique Lima da Conceição, Ana Carolina Machado dos Santos, Catharina Matos de Oliveira, Mariana Alves Antunes, Johnatas Dutra Silva, Philip S. Crooke, Fernanda Ferreira Cruz, Cynthia dos Santos Samary, Camila Marinelli Martins, Pedro Leme Silva, John J. Marini, Patricia Rieken Macedo Rocco

Institutions: Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Vanderbilt University, Universidade Estadual de Ponta Grossa, University of Minnesota

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Awards: G1277420855, G1559604903, G4406209143, G6465764514

OpenAlex ID: W7137905474

FWCI: 4.431

Cites: 29

Cited by: 1

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