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Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity

Year: 2026

Type: article

Abstract: OBJECTIVE: In osteogenesis imperfecta (OI), phenotypic variability and the limited predictive value of genotype-phenotype correlations underscore the need for reliable predictive marker of disease severity. Periostin is a matricellular protein involved in bone formation, remodeling, and response to mechanical stress. It interacts with type I collagen and modulates osteoblast activity via Wnt/β-catenin and TGF-β signaling. Given its established role in other bone disorders, we hypothesized that circulating periostin may be a relevant biomarker in OI. METHODS: We performed a matched case-control analysis of serum periostin levels in 61 adult patients with OI and 61 age-, sex-, and BMI-matched controls. Periostin was measured by ELISA. Associations between periostin levels and clinical variables were assessed using t-tests, Pearson correlations, and multivariable linear regression models. RESULTS: Mean periostin levels were significantly higher in OI patients than in controls (796.5 ± 209 vs 713.6 ± 167 pmol/L, P = .017). Among OI patients, higher periostin level was associated with female sex (P = .01), presence of scoliosis (P = .01), and Sillence type III (P = .05). Positive correlations were observed between periostin and markers of axial skeletal severity as height-wingspan discrepancy (r = 0.30, P = .023). In multivariable analysis, the number of severe fractures (defined as femur/pelvis/humerus/vertebral fractures) was independently associated with higher periostin level (β = 25.6, P = .041), while smoking was negatively associated (β = -269.8, P = .012). CONCLUSION: This study is the first to report the elevated circulating level of periostin in adults with OI and its association with disease severity.

Source: The Journal of Clinical Endocrinology & Metabolism

DOI: 10.1210/clinem/dgag119