Insights from Stem Cell and CRISPR-Based Therapies for Diabetes Mellitus: A Systematic Review
Year: 2026
Type: review
Study design: Systematic Review
Abstract: Diabetes mellitus (DM) is a metabolic disorder resulting from aberrations in insulin secretion or action. Diabetes mellitus still presents as a global health challenge. Conventional diabetes treatment may result in unwanted side effects and/or poor compliance. More personalized and curative approaches to the treatment of DM are required. The review explores recent developments in the fields of genetic and molecular underpinnings of DM, focusing on the revolutionary potential of cell- and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based genome editing (GE) technologies. An extensive literature survey was carried out using four common databases, the ‘Web of Science’, PubMed, ScienceDirect, and Scholar Google. CRISPR therapy targets crucial genes involved in diabetes pathogenesis. Early data indicate potential improvements in glycemic control among DM patients who have undergone CRISPR-driven modifications related to insulin production. Despite some technical, safety, and ethical limitations, the CRISPR/Cas9-mediated DM treatment is promising due to its sensitivity and specificity. The CRISPR-based DM treatment strategy is a novel, well-studied, sustainable, and more efficient alternative to traditional DM therapies.
Source: OBM Genetics
Author: Ahmad M. Khalil
Institution: Yarmouk University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W7138054305