Work

515P Multi-regional sequencing of oligometastatic non-small cell lung cancer patients reveals variations in clonal complexity

Year: 2026

Type: article

Abstract: In patients with oligometastatic NSCLC, local ablative treatment (LAT) including surgery and high-dose radiotherapy has been shown to provide a survival benefit if combined with systemic treatment. Nevertheless, molecular characteristics of “true” oligometastatic disease (OMD) are still poorly understood and patient selection for LAT remains a central challenge. Here, we aimed to investigate the genetic landscape of OMD by comprehensive next-generation sequencing (NGS) of primary tumors and metastases.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2026.106830