2026 Clinical Practice Guideline Update by the Infectious Diseases Society of America and the Pediatric Infectious Diseases Society on The Management of Community-acquired Pneumonia in Infants and Children Older than 3 Months of Age: The Use of tPa and DNase or tPa Alone for Fibrinolysis
Year: 2026
Type: article
Abstract: This paper is part of a larger clinical practice guideline on the diagnosis and management of parapneumonic effusion and empyema in children, developed by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. In this report, the panel provides recommendations for intrapleural fibrinolysis with tissue plasminogen activator (tPA) alone over tPA and dornase alfa (DNase) in children (3 months to 18 years) with complicated parapneumonic effusion and empyema. The panel's recommendations are based upon evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.
Source: Clinical Infectious Diseases
DOI: 10.1093/cid/ciag191
Institutions: Children's Mercy Hospital, University of Utah, Seattle Children's Hospital, University of Washington, Albert Einstein College of Medicine, University of South Florida, Northwestern University, Lurie Children's Hospital, Children's Hospital of Philadelphia, University of Pennsylvania, Washington University in St. Louis, Baylor College of Medicine, Texas Children's Hospital, University of California San Diego, Cincinnati Children's Hospital Medical Center, Vanderbilt University, Infectious Diseases Society of America, Boston Children's Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7138115525