Work

Kupffer Cell Capture-Evading Modifiable Sub-20 nm Lipid Nanodisc-Based 19 F Magnetic Resonance Imaging Probes

Year: 2026

Type: article

Abstract: F MRI probes with diameters of approximately 10 nm. The resulting probes exhibited a unique behavior in vivo, distinct from that of conventional probes: they avoided Kupffer cell uptake and were excreted via kidneys. MR signals remained detectable after surface modification. PEGylated nanodiscs exhibited a slower accumulation in the bladder compared with unmodified counterparts, likely due to their prolonged circulation time induced by PEG modification. With the potential to reach tissues previously inaccessible and be modified with various functional moieties, our nanodisc-based platform offers broad opportunities for biomedical applications, including visualization of diverse organs and monitoring of biochemical reactions in vivo.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c21753

Authors: Kodai Fukushima, Tomoya Yamamoto, Kazuya Kikuchi

Institution: The University of Osaka

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500