Work

334P Metabolic reprogramming of the tumor microenvironment in pleural mesothelioma highlights nucleotide metabolism–immune interactions

Year: 2026

Type: article

Abstract: Pleural mesothelioma (PM) remains a therapeutically challenging malignancy, in which treatment resistance is closely linked to the metabolic and immunologic properties of the tumor microenvironment (TME). Although altered cancer metabolism has been implicated in immune evasion and therapeutic refractoriness, the metabolic programs shaping the PM TME and their immunologic relevance remain incompletely understood. Building on our prior proteomic profiling, we further investigated the metabolic–immune interface in PM by integrating proteomic and transcriptomic analyses.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2026.106645

Authors: T. Tagawa, K. Yamazaki, T. Tokunaga, A. Haro, N. Miura, T. Takenaka

Institutions: National Kyushu Medical Center, Kyushu University

Language: English

Topic: Occupational and environmental lung diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910