Work

Mechanism by which Qingre Lishi formula regulates Behçet’s disease through gut microbiota-derived metabolites

Year: 2026

Type: article

Abstract: This research employs an integrated approach combining network pharmacology and molecular docking to assess the therapeutic potential of a Heat-Clearing and Dampness-Eliminating Formula alongside gut microbiota (GM) metabolites in the management of Behçet’s disease (BD). Active constituents of the formula and GM-derived metabolites were sourced from specialized databases including TCMSP, SwissTargetPrediction, PubChem, and gutMGene. Disease-associated targets for BD and metabolite-related targets were compiled using publicly available datasets. Through protein-protein interaction (PPI) network construction and KEGG enrichment analysis, pivotal targets and major signalling pathways implicated in BD pathology were identified. Molecular docking simulations further assessed the binding interactions between active metabolites and target proteins, corroborating the predictions derived from network pharmacology. Further experimental validation using in vitro and in vivo models is warranted to substantiate these computational insights.

Source: Artificial Cells Nanomedicine and Biotechnology

DOI: 10.1080/21691401.2026.2640825

Authors: Yannan Xia, Shuhui Du, Ming Li, Mingze Wu, Chuanbing Huang

Institution: Anhui University of Traditional Chinese Medicine

Language: English

Topic: Ocular Diseases and Behçet’s Syndrome

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,557