Work

245P cfDNA fragmentomics as a non-invasive tool for differentiating malignant from benign lung nodules: A prospective study focusing on small lesions

Year: 2026

Type: article

Abstract: Low-dose computed tomography (LDCT) effectively reduces lung cancer mortality through early detection but is limited by a high false-positive rate, often causing unnecessary invasive procedures and patient burdens. Circulating cell-free DNA (cfDNA) fragmentomics—analyzing fragment size distribution and end motifs—emerges as a promising non-invasive cancer detection strategy. This prospective study (MR-31-25-004765) evaluated its efficacy in differentiating malignant from benign lung nodules, focusing on small lesions.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2026.106553

Authors: Y. Zhang, F. Qian, B. Zhang, H. Zhong, B. Han

Institutions: Shanghai Jiao Tong University, Shanghai Chest Hospital

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910