347P Long-term outcomes of initial local therapy for oligorecurrence in resected EGFR-mutated lung adenocarcinoma
Year: 2026
Type: article
Abstract: compared with the control group and exosomes of A549 cells group.The miRNA sequencing results showed that miR-4746-5p was significantly overexpressed in the exosomes of PC14/B cells.Compared with HBMECs, the intercellular permeability of miR-4746-5p mimics HBMECs was significantly increased, and the expression of tight junction proteins was down-regulated.Conclusions: Exosomes of brain metastasis-prone cells could significantly downregulate the expression of tight junction proteins between HBMECs, thereby disrupting BBB and increasing its permeability, thus promoting the formation of lung cancer brain metastases.Exosomal miR-4746-5p may be involved in the regulation of brain metastasis, but the specific mechanisms remain to be further clarified.
Source: ESMO Open
Authors: S. Tsuchida, Y. Zenke, S. Takahashi, S. Ohtani, K. Nomura, T. Miyoshi, Y. Ohtaki, K. Tane, Y. Matsumura, K. Aokage, M. Tsuboi
Institution: National Cancer Center Hospital East
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,910
OpenAlex ID: W7138208533
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